Massimo Terzolo Selected Research

Adrenal Cortex Neoplasms (Adrenocortical Cancer)

10/2021	Molecular Mechanisms of Mitotane Action in Adrenocortical Cancer Based on In Vitro Studies.
9/2020	Unwanted Hormonal and Metabolic Effects of Postoperative Adjuvant Mitotane Treatment for Adrenocortical Cancer.
3/2020	Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma.
12/2019	Activity and safety of temozolomide in advanced adrenocortical carcinoma patients.
11/2017	Circannual variation of mitotane and its metabolites plasma levels in patients with adrenocortical carcinoma.
10/2017	Effects of mitotane on the hypothalamic-pituitary-adrenal axis in patients with adrenocortical carcinoma.
1/2017	Topoisomerase 2α and thymidylate synthase expression in adrenocortical cancer.
12/2016	Antisecretive and Antitumor Activity of Abiraterone Acetate in Human Adrenocortical Cancer: A Preclinical Study.
2/2015	RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization.
5/2013	Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates.

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Massimo Terzolo Research Topics

Disease

51	Adrenocortical Carcinoma 01/2022 - 09/2005
35	Neoplasms (Cancer) 09/2022 - 01/2005
27	Cushing Syndrome 03/2022 - 03/2002
17	Adenoma (Adenomas) 01/2022 - 03/2002
14	Adrenal Cortex Neoplasms (Adrenocortical Cancer) 10/2021 - 12/2008
9	Hypertension (High Blood Pressure) 03/2022 - 12/2006
9	Adrenal incidentaloma 01/2022 - 03/2002
6	Acromegaly 01/2017 - 01/2005
5	Disease Progression 04/2020 - 06/2012
5	Adrenal Insufficiency (Adrenal Gland Hypofunction) 03/2020 - 01/2008
4	Carcinoma (Carcinomatosis) 05/2021 - 05/2007
3	Type 2 Diabetes Mellitus (MODY) 03/2022 - 08/2016
3	Pituitary ACTH Hypersecretion 01/2021 - 06/2003
3	Hyperglycemia 01/2021 - 01/2014
3	Dyslipidemias (Dyslipidemia) 09/2020 - 12/2016
3	Hypothyroidism 09/2020 - 12/2008
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2012 - 01/2004
3	Adrenocortical Adenoma (Disease, Conn's) 12/2006 - 01/2004
2	Pheochromocytoma 06/2022 - 08/2016
2	Hypogonadism (Hypergonadotropic Hypogonadism) 09/2020 - 01/2013
2	Obesity 03/2019 - 12/2016
2	Neoplasm Metastasis (Metastasis) 11/2018 - 08/2016
2	Fatigue 09/2018 - 04/2015
2	Nausea 09/2018 - 04/2015
2	Acute Intermittent Porphyria (Porphyria, Acute) 01/2018 - 01/2018
2	Adrenal Gland Neoplasms (Adrenal Cancer) 02/2015 - 01/2014
2	Necrosis 08/2014 - 09/2013
2	Prostatic Neoplasms (Prostate Cancer) 12/2013 - 01/2011
2	Hyperaldosteronism (Conn Syndrome) 03/2012 - 04/2009
2	Hyperplasia 03/2012 - 05/2007
2	Addison Disease (Addison's Disease) 01/2008 - 10/2006
1	Thrombosis (Thrombus) 09/2022
1	Congenital Abnormalities (Deformity) 01/2022
1	COVID-19 12/2021
1	Breast Neoplasms (Breast Cancer) 01/2021
1	Hypokalemia 01/2021
1	Pituitary Neoplasms (Pituitary Adenoma) 01/2021
1	Glycosuria 01/2021
1	Uterine Hemorrhage (Uterine Bleeding) 01/2021
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2021

Drug/Important Bio-Agent (IBA)

37	Mitotane (Lysodren)FDA Link 09/2022 - 09/2005
26	Hydrocortisone (Cortisol)FDA LinkGeneric 03/2022 - 03/2002
15	Pharmaceutical PreparationsIBA 10/2021 - 06/2010
10	Hormones (Hormone)IBA 01/2022 - 06/2003
8	Dexamethasone (Maxidex)FDA LinkGeneric 03/2022 - 06/2003
8	GlucocorticoidsIBA 01/2022 - 01/2006
7	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2021 - 06/2003
6	SteroidsIBA 03/2022 - 12/2011
6	Biomarkers (Surrogate Marker)IBA 05/2021 - 12/2011
4	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2022 - 01/2016
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 03/2002
4	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2021 - 02/2014
4	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2020 - 09/2005
4	Insulin-Like Growth Factor I (IGF-1)IBA 01/2017 - 01/2005
3	Antihypertensive Agents (Antihypertensives)IBA 03/2022 - 10/2008
3	Insulin (Novolin)FDA Link 03/2022 - 01/2014
3	relacorilantIBA 01/2022 - 01/2021
3	Growth Hormone (Somatotropin)IBA 01/2021 - 02/2014
3	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2021 - 01/2014
3	Cisplatin (Platino)FDA LinkGeneric 04/2020 - 09/2005
3	Etoposide (VP 16)FDA LinkGeneric 04/2020 - 09/2005
3	Metyrapone FDA Link 09/2018 - 01/2018
3	AndrogensIBA 01/2018 - 01/2013
3	2,2- (2- chlorophenyl- 4'- chlorophenyl)- 1,1- dichloroetheneIBA 11/2017 - 06/2011
3	2,2- (2- chlorophenyl- 4'- chlorophenyl)acetic acidIBA 11/2017 - 06/2011
2	PlatinumIBA 09/2022 - 10/2021
2	AntibodiesIBA 12/2021 - 05/2013
2	Proteins (Proteins, Gene)FDA Link 05/2021 - 01/2017
2	MineralocorticoidsIBA 09/2020 - 12/2013
2	Abiraterone AcetateIBA 11/2019 - 12/2016
2	EnzymesIBA 11/2019 - 08/2004
2	Progesterone FDA LinkGeneric 01/2019 - 12/2016
2	Testosterone (Sustanon)FDA Link 09/2018 - 12/2008
2	Heme (Haem)IBA 01/2018 - 01/2018
2	LigandsIBA 01/2017 - 02/2014
2	Steroidogenic Factor 1IBA 08/2014 - 05/2013
2	Gemcitabine FDA Link 01/2014 - 06/2010
2	abirateroneIBA 12/2013 - 01/2011
2	Reticulin (Reticular Fiber)IBA 09/2013 - 12/2011
2	AldosteroneIBA 03/2012 - 04/2009
1	ElementsIBA 06/2022
1	Cortisone FDA Link 01/2022
1	Hyaluronan SynthasesIBA 05/2021
1	OsteopontinIBA 05/2021
1	Laminin (Merosin)IBA 05/2021
1	ParaffinIBA 05/2021
1	Aromatase (CYP19)IBA 01/2021
1	Sodium-Glucose Transport ProteinsIBA 01/2021
1	Denosumab FDA Link 01/2021
1	Mifepristone (RU 486)FDA Link 01/2021
1	pentetreotide (OctreoScan)FDA Link 01/2021
1	Aromatase InhibitorsIBA 01/2021
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2021
1	Alkylating AgentsIBA 04/2020
1	TrabectedinIBA 04/2020

Therapy/Procedure

27	Therapeutics 03/2022 - 01/2006
9	Drug Therapy (Chemotherapy) 09/2022 - 06/2010
6	Adrenalectomy 09/2018 - 01/2004
2	Aftercare (After-Treatment) 01/2021 - 10/2008
1	Adjuvant Radiotherapy 09/2022